This is kinda interesting. It almost sounds to me like brain plasticity on overdrive, where you can basically dictate the interpretative model your brain uses to create reference points for what it's going through.
It also suggests that there are additional subconscious layers beyond what drugs temporarily make consciously accessible, which this particular compound is activating and causing to behave in a way that filters an experience down that matches a certain set of experiential memories.
Also makes sense why removing all the filters and going straight for "let's see what this thing really is" produces uncomfortableness - the distorted mess that comes out of a set of overdriven speakers is painful, semantically meaningless, and entropic to the point of having no discernible pattern.