SproutCore 1.x, the current stable line, is in use for a number of major sites that work across a large number of browsers, including IE7 and IE8.
@tomdale's comment above provides some context for the rationale behind using a developer preview for this site: http://news.ycombinator.com/item?id=2598829
I must admit I haven't checked right now, but at least a few months ago the site was all about how awesome Sproutcore is, but accidentally neglected to mention that there are common browsers on which it does not work. I had to install and try to use it to figure that out.
IMHO this is a serious attitude problem; launch first, make work later. That's all right if you're open about what's missing, but the Sproutcore site makes promises ("it works") that it can't keep.
That's what I get now using Opera 11.11 32bit on Linux.
Uncaught exception: ReferenceError: Security error: attempted to read protected variable: toString
Error thrown at line 9, column 22266 in x(a, b, c) in http://www.everyjs.com/js/libs/sproutcore-2.0.a.3.min.js:
if(g&&g.toString===e)