The hubstore has its own packaging format, as opposed to standard approach, such as a .whl file with entry_points of setup.py. As a result, you cannot use any of the pre-existing python apps. And if someone makes hubstore-compatible app, it is not going to be usable with regular python tools by default.
The Pyrustic is kinda the same -- it has some cool components, but it also requires a lot of buy-in. I could use better TkInter widgets, but I am not even going to consider it if it requires some sort of interactive, non-scriptable wrapper shell which completely destroys all my existing workflows.