However, having a monolithic compiled Wasm module which contains all of (and only) the rendering logic is really nice on a codebase-level.
Also, the Wasm part of Micrio is being used for a lot of realtime matrix4 calculations. While I didn't use this specific library, here is a bench page which shows that Wasm really kills JS performance here: https://maierfelix.github.io/glmw/mat4/ .
So it definitely makes a difference. If I had the time I would port the Wasm engine back to JS and do more benchmarking. But that's a big if :)