Imagine a robot trying to argue that it doesn't if they live in Westworld; I mean, the robot bar tender still has to tend bar. Imagine Truman trying to convince himself that it doesn't matter if he's in a TV show or not.

Their arguments, no matter how clever, would be absurd when looking in from the outside.

If there's a high probability that the simulation hypothesis is true, it seems clinically insane to believe that it doesn't matter.