One thing I thought I hated about the Ergodox was how inaccessible the small keys on the thumb cluster were, and I thought I would like 3 big keys better. It turns out not to be the case... those keys are useless, but there are a lot of useless keys that are nice to have around (arrows, delete/insert, home/end, pgup/pgdn). I mostly do everything in Emacs and so don't use those keys, but when I'm using non-Emacs software, I do miss them.
(I ultimately decided on Backspace, Alt, Up; Space, Enter, Down as what I use the big thumb keys for. Not sure I love this. This transitioned my backspace key from my right pointer finger to my left thumb, and it broke my muscle memory. I still forget that you can control backspace words to kill them outside of Emacs (where I use C-w for that, which closes your window in every other program).)
TL;DR: it's fine! But still not perfect.