> We could fuzz it and see if we can crash a brain.
Sadly, this we already know. Torture, fear, depression, regret; we have a wide selection to choose from if we want to "crash a brain".
Think for instance of a song that got stuck in your head. It probably hits some parts of it just right. What if we could fine tune that? What if we take a brain simulator, a synthesizer, and write a GA that keeps on trying to create a sound that hits some maximum?
It's possible that we could make something that would get it stuck in your head, or tune it until it's almost a drug in musical form.
Well, except when they don't, but since a brain functioning as a brain is part of the operating requirements for the body that lets the brain operate at all, when they don't, they ultimately fail entirely in short order.
So, assuming that a brain generally operates as a brain after severe trauma is a pretty serious case of survivorship bias.