For those looking to ‘de-Google’ their lives, and control their own data Nextcloud is one of the best options out there.
I actually virtualize unraid within esxi so that one small 1U box can be my router / firewall and an unraid machine serving home services. Best setup I’ve ever had and learned so much along the way!
I run a cheap EC2 instance, and plug it into an S3 bucket for file storage, and my RDS MySQL database.
In my case, for purposes of hobby projects and various self hosted services, I keep both MySQL & Postgres RDS instances running in perpetuity, both t3a.micro. On demand pricing is roughly $13/month, but since I plan on keeping them running 'forever' I purchase reserved instances. For a 3 year plan, 'no-upfront', this brings the cost down to about $8.75/month. Much more palatable if you ask me :)
Also, I use them for multiple projects, so the convenience factor is worth it for me. For your NC alone, I imagine it would be good enough to just run you DB server on the same EC2 instance. I doubt the database storage would eat up much disk space.
You could however, rip through a ton of disk space from file storage, so I feel like S3 buckets are a must, and cheap anyway.
It syncs everything, the iOS app and web dashboard are adequate. I would recommend it (but I haven't tried anything else, other than Google Drive or Dropbox, of course)
I could nuke the app server, change hosting providers, or if there was a hardware failure or whatever, it won't matter. I can always spin up a fresh server, and plug back into my external DB and data store.