Drones are cheap, good missiles are 1/100th the price of an F-35. It's possible that aircraft will no longer be able to enter contested space without significant risks just as it was pre-ww2 where it was impractical to achieve air superiority or to destroy anti-aircraft placements.
Considering the extreme investment of the US into aircraft as a means of projecting power and winning wars against conventional militaries, there is a chance that an opponent with a much smaller military budget could "win" in a conventional fight - making the multi-trillion dollar aircraft projects pointless.