I lived out of a minivan and then a larger fan for 2.5 years while writing software and loved it.
It was one of the most freeing and enriching experiences of my life, and was so much better than living in a stationary building.
I traveled all around the country and was still able to remain productive. In fact, I was more productive and motivated, because my life was actually interesting and different day-to-day.
It was sometimes uncomfortable, especially in the beginning when I learned the ropes, but nothing too bad. (This is in the U.S., where it's safe to do in majority of places.)
In my gradual cutting of monthly upkeep expenditures I had to give it up in favor of more detached living, but it was great, and I would do it again if I didn't have to do paid work to accomplish it.