What about those weirdos who deliberately choose to use the abomination that the web stack is for desktop apps? To me it feels like they're trying to write real GUI apps in Word macros. I don't think I'll ever understand why.
Now? You need Windows desktop, mobile on 2 different operating systems, web, MacOS, and possibly TV depending on your market.
What's the lowest common denominator? Web stack.
I only have a problem with the ones among those hammer only people that are proud of not knowing anything else and proclaim everybody not using a hammer for everything stupid, because "look on all those perfected hammers we created! your choice doesn't have such nice ones".