For a typical laptop, Secure Boot plus Full-Disk Encryption (e.g. Windows BitLocker) makes it harder but not impossible for an "evil maid" - an attacker with temporary, undetected access to the hardware - to compromise the system. (Note that Qubes' VM isolation, per se, does not help in an "evil maid" scenario! - the evil maid typically never even turns the system on.)
There's a lot to say about Secure Boot, and Intel's "measured boot" is rather different from the usual authenticate-then-start approach. If you want to know more, Rutkowska's (of Qubes OS fame) "x86 considered harmful" has quite a lot of good information.
[EDITed to properly spell Rutkowska’s name; thanks, e Erik!]