One of my projects (DBHub.io) is putting effort towards working through the problem with larger sized SQLite databases (~10GB), and that's mainly through using bare metal hosts with lots of memory. eg 64GB, 128GB, etc.
Putting the same data into PostgreSQL, or even MySQL, would likely be much more efficient memory wise. :)
dolt remote add <remote> file:///Users/xyz/abs/path/200GB databases for PostgreSQL (etc) isn't any kind of amazing.
So, resource usage is pretty much not a consideration in any way when doing things with them.
Once people start doing things with multi-GB databases though, if the system they're running on has a small amount of memory (say 4GB, 8GB) then things can start going poorly.
Not like "crash and burn" poorly (so far). More like "tries to read 10GB of data into 4GB of ram" poorly. eg Dog slow, not lightning quick.
If your machine has a bunch of ram in it, you're likely safe . Though, I'd be making damn sure there are tested and working backups of it, just to be safe. :)