Imagine just one aspect of this. A thyroid disorder.
If the donor body was hyperthyroid, the head transplant would result in someone with the symptoms of hyperthyroidism. Angry, irritable, racing pulse, etc. If they had hypothyroidism, they would be depressed, lethargic, etc.
And that's just one organ in the body. It could radically alter the "person" who they are presuming lives only in the head.