1. It's oblong with few safe surfaces to touch. To carry it with one hand forces you to hold it from one edge at least for awhile each time you pick it up and put it down. That feels heavy because of the leverage it pulls against that little edge you get to hold.
2. By opening frontwards/away from you, opening feels bad. Compare with opening a tablet that folds horizontally like a book.
3. It's often hard to find a clear spot to fit your laptop footprint at home. Corollary: when most people are not using it, it takes up a lot of desk or counter space. Very few people store it vertically. I store mine vertically under my desk and it gets kicked a lot.
4. It's really hard to just keep it closed and use it as a desktop replacement. Most have power buttons on the inside only, so when you have to wake it up or reboot, you've got to open it a crack and wedge your finger in there.
5. You can't tell how much battery is left, or what time it is, or when your next appointment is, without opening up the lid. Often you have to do one of those things while walking. Opening the lid and checking something on the inside while walking feels terrible.