CBD reduces plaque, improves cognition in mouse model of Alzheimer’s

The reason is, there are very limited choices in which mouse line to use. You basically have to pick from a menu of transgenic mice from some supplier. So you would have to be lucky enough that a supplier breeding transgenic mice just happens to have picked, with an educated lucky guess, a combination of genes that expresses a disease enough like Alzheimer's when spliced into a non-human host that something that has some effect on the mouse disease also has an effect on the human disease, compounded with being lucky enough to find a treatment for the mouse disease at all, compounded with the luck of picking that mouse line from the menu of dozens of mouse lines with human genes spliced in.

So lets say a time traveler from the year 2321 hands you a vial with the cure for Alzheimer's in it, and you want to test if it works. So you open the mouse catalog, and you see a dozen transgenic mice choices. Lets say, by some cosmic coincidence, one of those mouse lines out of the dozen choices, again by luck since it's unlikely that out of a couple of spliced genes they would ever happen upon a mouse line that it would ever work, has the right gene that coincidentally the human cure will also work on that line of mice. By far the most likely outcome (11/12 times) is you order mice, they are acting like they have a brain disease, you inject them with the future cure and it doesn't help them at all. This is when you know for a fact you do have a cure for humans. This is why I'm saying these mouse studies are a waste of money and research effort. If you have a cure for Alzheimer's the mice are very unlikely to show improvement, and things that improve the behavior of the mice are incredibly unlikely to work in humans.

So why do they do it? Well, there is a big pool of money available to study Alzheimer's and there are catalogs with mice in them, and you can inject mice with whatever random thing you want without a lot of 'having a reason it might work'. It's like the guy looking for his keys under a street light. When you ask him if that's where he lost his keys he says "No, I lost them way over there." Ok why not look where the keys might be? "It's too dark to see over there". In this case, it's "we don't know how to do an experiment that might be useful but there is funding and we can order mice".

I recommend getting CBD cannabis, making edibles or smoking it. I mix it 1:1 with THC weed, and smoke to a point I'm not high. It's been one of the best things that I did for my mental health, up there with getting a cat, going to therapy and getting regular exercise.

Which brings us to Alzheimer's. Mice don't get Alzheimer's. Instead, mouse models for Alzheimer's work by attempting to genetically induce something that we think might be how Alzheimer's develops in humans. Except, we don't actually know that much about Alzheimer's: the dominant theory, and hence the basis for mice models, involves amyloid plaque formation, but amyloid beta blockers have had ruinously expensive clinical failures which makes the theory rather difficult to believe. So anything that shows improvement in Alzheimer's in mice is pretty worthless as a result.

Or you can go the unethical and often illegal human testing route which is also a more mixed bag of results than would be ideal.