Humans aren’t rational.
I don't know how you know that. Given the significant time and effort required to become a doctor, isn't it at least as likely that they are motivated about people not dying on any lawn?
https://covid19criticalcare.com/medical-evidence/methylpredn...
What about the Hippocratic oath? First do no harm.
A handful of unjust police killings cause widespread protest / riot / unrest, but 15,000 unprevented homicides are largely accepted as part of life.
You can argue that they are morally equivalent, but our brains get more angry at someone doing a bad thing than at someone not doing a good thing.
Most of the public doesn't care or understand, neither do the politicians. Not interesting to fix because no one intentionally did anything bad? And, spending time on this won't win any elections?
I don’t think that beurocrats are supposed to be leaders. The elected officials should be pushing for the change, not the people who run the operations.
Of course this is an exaggeration, but there is a somewhat disturbing neglect of EU elections, functions and political appointments in the public view (it's seen as less prestigious than national/federal elections in many EU member states).
As a result, it's a climate that doesn't always attract and get the leadership it really needs (given that the EU formally and practically overrules legislation and jurisdiction of member states).
This would explain why the Swedish state were so heavily criticised for not locking down. Also would explain the UK government arresting people for being outdoors (there's not really any data supporting outdoor transmission, that I know of).
What if that turns out to be more difficult than you originally realized.
The best strategy (however cynical) is to not be quantitatively explicit about expectations so that you can frame it as though you succeeded no matter what happens.
Also the symptoms are bizarre, the deaths and hospitalizations from blod clot have all been young health care workers in good health with onset of symptoms a few days after getting their first shot. They have all had low platelet count which is very unusual with blood clots and complicates treatment immensely because the standard thrombolytic treatment is then not safe to use.
It's absolutely mad for Italy, Austria etc.
But this is not a surprise: countries that handle the pandemic well (evidence based rather than populism or dogma) continue to manage the vaccine rollout well, and vice versa.
But as more blood-clot deaths emerge... you gotta think caution is wise.
OTOH yes, we in the UK have administered a lot of this stuff, and you'd think someone would have noticed a serious side effect like this. So far reports from the UK seem to show no greater incidence of blood clot problems than would be expected without the vaccine.
Difficult to call, but I hope it's all being investigated thoroughly.
We don't have time for that, we can't wait for some government panel to announce in 2025 "actually the blood clots were no more common than in the general population"
I hope it's being invested thoroughly by the people that know this stuff inside out, from AZ, Oxford and doctors on the ground where this has happened
Damn right a government panel is useless here!
Germany for example has nearly 2 million doses they are delaying, so that's ~300 deaths per day that are caused by these delays. If you delay by a fortnight that's more deaths than on 9/11.
Apparently EU vaccines are produced in Europe, maybe there's something wrong in the local production facilities that's causing this. UK has only used AZ vaccines produced in the UK, afaik.
I would challenge the term "caution", as it implies giving the vaccine is more risky than not.
> Difficult to call, but I hope it's all being investigated thoroughly
I agree there. But rather not for medical reasons.
I suppose it depends on the alternative - if it's "not having the vaccine" clearly that's worse. If it's "controlling the death rate by prolonging lockdowns" then that's clearly not desirable either, but not quite as bad.
If it's just "give a different vaccine", then that would be no problem. Of course then there are the supply issues it's unlikely that simple.
The majority of people getting the vaccinations are older. Perhaps we will see more cases will emerge for the younger age groups.
Important point! I start to get anxiety that there might be some Chernobyl level incompetence building up in our bureaucratic countries. I feel like we are getting to levels of a huge quantities of regulations, where then to unblock the process, relevant regulations are relaxed to be able to move forward, leaving us with a lot of regulations that make us feel safe, while the elephant in the room is building up through other valves. I fell like the 737 max thing also more or less fits this framework. So for the future: Let them incentives be aligned and them regulations work in the right direction!
> I don’t know anyone in pharmacovigilance who thinks what is happening now in EU states is rational based on known information.
> EMA had this right last week. We are seeing panic spread at EU state level.
https://twitter.com/isth/status/1370424157947752452
> The [International Society on Thrombosis and Haemostasis] recommends all eligible adults continue to receive the #COVID19 vaccine, despite recent decisions by some countries to at least temporarily suspend the use of the AstraZeneca vaccine due to reports of thrombosis. Read the full statement here: https://isth.org/news/556057
Last I saw it's 30 blood-clot deaths. Given the number of people that have received the vaccine that's a tiny, tiny amount. Even if those 30 were directly linkable to the vaccine (and so far no such link has been proven) you could still make the argument that the benefits of mass vaccinations outweigh the concern.
I don't envy anyone in charge of making those choices, though.
Usually I don't read notes coming with meds, but I am almost sure that even everyday stuff has potentially deadly side effects in the ball park number of the blood cloths AZ is causing.
And there would probably be an investigation into that the moment people using them showed up growing a third arm instead of getting a trombose.
Yes, some drugs have pretty nasty side effects, but vaccines are rather special, because their acceptance affects the entire society and vaccine safety is a sensitive topic, especially in a climate of skepticism. Undermining the idea of vaccine safety will be much worse than Covid (at least at this time).
The equation changes when otherwise young and healthy individuals are at risk of serious complications, even if exceedingly rare.
As far as I know by now a bunch of European countries have already suspended vaccination with the AstraZeneca vaccine. These include France, Germany, Italy and the Netherlands - not really a politically homogeneous bunch.
People (especially on HN) like to say "correlation doesn't equal causation", but there isn't even a correlation here. There are not higher rates of blood clots.
That being said a lot of Europeans who would come to the UK would be appalled by the quality of NHS compared to other European countries.
So I would argue that I would trust what German NHS says more than the British one.
Litterally all members of the same economic and political Union. The EU.
Pfizer: https://assets.publishing.service.gov.uk/government/uploads/...
AstraZeneca: https://assets.publishing.service.gov.uk/government/uploads/...
Disclaimer from UK.gov:
Part of our monitoring role includes reviewing reports of suspected side effects. Any member of the public or health professional can submit suspected side effects through the Yellow Card scheme. The nature of Yellow Card reporting means that reported events are not always proven side effects. Some events may have happened anyway, regardless of vaccination. This is particularly the case when millions of people are vaccinated, and especially when most vaccines are being given to the most elderly people and people who have underlying illness. https://www.gov.uk/government/publications/coronavirus-covid...
Edit: Added disclaimer from UK.gov
Slightly different reporting periods but I'm pretty happy with the odds and I'd take either if offered.
Anyway, here's the UK's disclaimer from the Yellow Card summary link you posted.
Part of our monitoring role includes reviewing reports of suspected side effects. Any member of the public or health professional can submit suspected side effects through the Yellow Card scheme. The nature of Yellow Card reporting means that reported events are not always proven side effects. Some events may have happened anyway, regardless of vaccination. This is particularly the case when millions of people are vaccinated, and especially when most vaccines are being given to the most elderly people and people who have underlying illness.
I suspect it's probably "possible side effects and deaths within 28 days of administering a vaccine", in the same way that the UK records "deaths within 28 days of a positive COVID test". One does not imply the other was the cause. (edit) other commenter points to the official UK docs.
Even with that information, you need to know the non-vaccine incidence of the illnesses in that report to make any meaningful comparison and assessment of the efficacy of the vaccine. Which is what I rely on scientists to do.
From the horse's mouth:
Ann Taylor, Chief Medical Officer, said: “Around 17 million people in the EU and UK have now received our vaccine, and the number of cases of blood clots reported in this group is lower than the hundreds of cases that would be expected among the general population. The nature of the pandemic has led to increased attention in individual cases and we are going beyond the standard practices for safety monitoring of licensed medicines in reporting vaccine events, to ensure public safety.”
https://www.astrazeneca.com/media-centre/press-releases/2021...
Can we please fucking stop the downvotes?
The Yellow Card scheme and similar schemes are not useful for direct analysis, they're basically an aggregator for anecdotes. I had a mysterious craving for a kebab after the flu-like side effects from the Oxford vaccine subsided. Probably nothing. I'm not going to waste a doctor's time with a video appointment to report "I suddenly really wanted a kebab". But while musing about it I might as well fill out this web form (with the other boring side effects too), then it goes in the big pile and hey, maybe over the millions of shots given in this country they find 8000 people reported a craving for a kebab which is enough to be interesting even though it's unclear how that could happen or what you should do about it.
Medics are going to write a lot more of these. Patient comes in with unexplained back pain, can't recall any triggering incident, but they did get the Pfizer vaccine 10 days ago? It goes in a Yellow Card report. Again, probably nothing, patients turn up with unexplained back pain all the time, vaccine or not. But collecting these anecdotes gives us a better chance to spot real problems early, so long as we don't mistake them for serious data.
Imagine they went against this recommendation and it turns out there is indeed an issue with the vaccine. That would cause a shit storm of epic proportions. This way the "worst" that can happen is that there was a delay.
Now people could die during that delay because they weren't vaccinated, but it's much easier to sweep that under the rug as a politician, in my opinion.
If mostly old people die from COVID but the adverse reaction of the vaccine is independent of age, then for very young people the risk of an adverse reaction of the vaccination might outweigh the risk of permanent damage from COVID.
But it doesn't mean that you will surely get COVID if you refuse to get a shot. Also, some people claim the vaccines are not very effective against some variants such as the South African one. So it means you can get vaccinated, suffer some serious side effects, and once you are recovered, get COVID.
And not just because of the obviously higher risk associated, but also because it appears not to be effective against the new strains. (Especially the new South Africa strain). Unlike for example the Janssen vaccine (goes by their parent company of Johnson and Johnson in the US) which was actually validated in South Africa or the rna ones which are just a technical masterpiece.
Keep in mind that the real shortage of vaccines is production locations right now. And the type of production of the Janssen, AZ and the Sputnik vaccine is all similar. So why even produce more of the worst vaccine in any of these locations.
Regarding the strains, all vaccines are less effective against the South African one.
Maybe they won't let you know, to avoid people refusing to get the AZ "vaccine".
How long until you can buy it? This way it's not a (possibly corrupt) politician deciding which corporation will make the stuff that gets into your body.
BTW I literally just had the Astra Zenica vaccine here in UK - I have a sore arm, lets hope I don't get any of the reported side effects!
Make sure to get plenty of water and rest :)
Also weekly report of the covid-19 vaccine side effects here: https://www.gov.uk/government/publications/coronavirus-covid...
Had my jab 3 hours ago, and enjoying a nice honey dew pomelo as I type thinking, fruit just don't get any better than this.
Germany has high rates of vaccine hesitancy. One way to tackle that is to be extra cautious. So, as soon as there's information about problems the vaccination programme is halted, an investigation is carried out, accurate and clear information is then presented showing rates of harm in unvaccinated and vaccinated people, and the programme is restarted.
The majority of the vocal deniers is localized around Munich btw, same with homeopathy advocates. Not sure why that is but I suspect 1888's medicine book by Eduard Bilz, which was extremely popular in Germany, could play a role (https://de.wikipedia.org/wiki/Bilz-Buch).
It's going to be interesting to see if western europe doubles down on the anti-vax beliefs or they swing round to be more like the Ossis.
[1] has a chart showing the percentage of kids born in 2012 getting full measles vaccination within their first two years by county.
[1] https://www.sueddeutsche.de/bayern/oberbayern-murnau-hauptst...
Just a thought with zero data behind it...
Twitter thread with some commentary & sources:
The Irish reasoning for suspending AZ wasn't just because of blood clots but blood clots in the brain which have a completley different severity.
https://www.astrazeneca.com/media-centre/press-releases/2021...
https://www.theverge.com/2021/3/7/22318113/russia-intelligen...
When you plot the infection and death rates of the vaccinated vs the unvaccinated population, the rates in the vaccinated group drop like a stone. The effect is highly significant.
The vaccination strategy is highly effective and is absolutely a major contributor (if not the primary contributor) to the decline.
'See, we were right not to vaccinate this fast'
For the downvoters: https://www.theguardian.com/commentisfree/2021/mar/15/eviden...
First it was efficiany with elderly in the study, were the numbers were totally misunderstood. Then it was overall effectiveness, then prevention of severe cases. The list goes on. In the meanwhile, the press is reporting every single rash people get with AZ.
EDIT: Just checked, they found 7 cases of thrombosis in the brain, out of 1.6 million vaccinated people. Well, we'll see how that develops.
I don't think they are trying to get revenge. They are trying to cover for their own failings. By any reasonable means, the vaccine rollout in continental Europe in relation to the wealth and logistics available compared to US/UK is a complete failure.
Goals and announcements have already been missed, and it turning out to be unnecessary can be muddied, or buried.
Assuming this is indeed politics, there are a lot of positives to this type of move in an already shit situation.
And yes, governments are doing everything they can. And the screw up with vaccinations. No idea why, because I don't have all the details, but maybe AZ is just coming in time to have been 1) a good scape goat early on when one was needed during the frustration with vaccine deliveries 2) bad at PR 3) earned a bad rep and now everybody is over cautious. And public / media pressure isn't really helping.
Except, you know, order enough vaccines for their population. Other than that though, everything that they can!
Am I missing something, how's that supposed to help ?
The alternative Pzifer jab is 10-20 times as expensive.
That is a lot money, some of which may find its way to work the media and the decision makers.
https://www.ft.com/content/c474f9e1-8807-4e57-9c79-6f4af145b...
AstraZeneca vaccine document shows limit of no-profit pledge
Company has right under contract to declare pandemic over by July 2021