I'm just using it to get my job done, and really couldn't imagine working with Python without it.
I'd consider static type checker as optional if you are playing around with small or throwaway scripts, but for any half serious project, it should be a requirement.
IME I don't consider it slow, and it's definitely not visibly slower than pylint, flake8, or similar tools for other languages.
Dropbox, which has one of the biggest Python codebases, uses it, and most mypy maintainers including Guido work there.