Correct me if I'm wrong, but given the P2P nature of bitcoin, wouldn't it effectively give someone interested in malicious activity a list of target IP addresses? In theory he could set up his own P2P, watch for large transactions, and then he has an ip running a bitcoin client who (potentially) has a large wallet.
Then it's just a matter of running common exploits (or new ones, if you have them) in order to access the machine and the bitcoin wallet.