The moral of the story is: don't have employees. Have contractors.
This is why most companies hire software contractors via companies who employ multiple contractors, and never directly.
PDF warning: [1] http://www.irs.gov/pub/irs-utl/x-26-07.pdf see pages 3-5
Edit: just read your top-voted post. If you can swing it, definitely go for it. I just think it is way too much paperwork and a bootstrapped startup probably couldn't afford it.
Actually the IRS has very vague and inconsistent rules about who can be considered an employee or a contractor. Look them up and manufacture facts and documentation to stay as far on the right side as you can.