Depending on the game you're playing, that may or may not be an issue.
It can stop you connecting to certain players in a peer to peer scenario.
As another example, last time I checked WebRTC didn't use UPnP, but has all the same issues as a fundamentally P2P UDP protocol. They use STUN/ICE/TURN, live uses custom protocols filling the same niches.
https://support.xbox.com/en-GB/help/hardware-network/connect...
I don't think anything has fundamentally changed in this area since the days of the Xbox 360. Back then it was a PITA to get two or more consoles working properly without UPnP, and I can't see anything about the problem that would be different now.
Nintendo has a similar page:
https://www.nintendo.co.uk/Support/Nintendo-Switch/Troublesh...
So does Sony:
https://manuals.playstation.net/document/gb/ps4/settings/nw_...