In the last 60 years, computers have gone from $160 billion/GFLOP to $0.03/GFLOP; transistors are now smaller and faster than synapses by the same factors that wolves are smaller and faster than hills, and the sort of computing tech that was literally SciFi in the 60s — self-teaching universal translators, voice interfaces, facial recognition — is now fairly standard.
60 years of biotech? If the next time I wake is after 60 years in a cryonics chamber[0] and was told every disease was now cured, that every organ could be printed on demand, that adult genetic modification was fine and furries could get whatever gene-modded body they wanted up to and including elephant-mass fire-breathing flying dragon, and that full brain uploading and/or neural laces a-la The Culture were standard, I would believe it. But if they told me biological immortality was solved (as opposed to mind upload followed by download into a freshly bioprinted body with a blank brain) I’d doubt the year was really only 2081 — not all research can be done in silicon, some has to be done in-vivo, and immorality would be one of them.
[0] this would be very surprising as I’ve not signed up for it, but for the sake of example