One thing I'm using that I've seen crop up on this thread is tailwindcss... I've not used it before but I'm really enjoying it so far. It's not a panacea by any means - it makes no attempt to help you organise your CSS or make it modular so you need to 'bring your own discipline'. For example, it's fairly easy to end up with inconsistent design because it makes it so easy to just add a few custom tweaks here and there. That same feature also makes it easy to duplicate information.
That said, for the first time I feel like I can actually iterate quickly on CSS and design in general. That probably says more about me than CSS but I'm having a blast. The fixed set of choices and short/consistent class names mean that I spend less time reading docs and more time iterating, which is great in my book.
Maybe it's an approach that doesn't scale well to teams? Maybe I'll regret it later? Can't comment on that yet but it has certainly given me a step change in CSS productivity.
The rest of the tech I'm using is all pretty dull, with one exception, which is that I'm using the platform to host itself (the backend at least).
Hopefully this doesn't count as too much of a shameless plug but it certainly fits the bill of a 'different approach' as I'm the only user right now!!
The (very basic) landing page is here: