Twitter. From generic caches to ad serving; from stream processing to video encoding, all high utilization applications of either one or multiple schedulable resources.
Granted Twitter operated one big shared Mesos+Aurora offering for everything*, the whole cluster high utilization wouldn't give much flexibility to absorb load, or do reasonable capacity planning (which was an entire org in itself) when you own and operate those machines and data centers. I can't comment much on the 20-30% figure given in MesosCon, it's been more than 5 years since I was last privy to these figures.