JMAP is an extension of the email protocol stack; it only replaces IMAP.
TMTP is an alternative to the entire email protocol stack. It will be standardized after it's been proven in a range of real-world scenarios.
The mnm client & server, which implement TMTP, work well today, and have nearly all the features most users need. See docs menu in the online demo.
https://mnmnotmail.org/demo.html
Re "serious money", could you elaborate?