The most likely issue you will encounter with trying to connect many I2C devices is address collisions where devices have fixed addresses or at least some fixed bits in the address. This will probably limit you to about twenty or thirty useful devices on a bus.
So you either have way to set the address using resistors / address lines or you have some config more where you set the configuration for the sensors one by one (Cypress touch sensors had this)
This is sometimes done, though more commonly in my experience is there are some input pins which the chip uses to determine the actual address.
This might be as simple as one to three inputs which should be connected to ground or supply voltage to encode the last bits of the address.
Other chips are a bit more creative, and allows you to, in addition to ground and supply, tie the address pins to the I2C clock and data pins. This allows it to generate four combinations from per address pin.
Far more interesting in that regard is the SMBus, that is compatible in most cases with I2C but can handle things like address resolution.