Those 2 years were already enough to pick up some legacy cruft and special cases. us-east-1 is also the first region for various other old services, like s3 and route53.
I think it's also the largest region across many axis, which naturally means it will hit various scaling issues before other regions.
Took out a few of our production databases, seems like Australia is the beta testing region for at least a few services.
At least in the US you have the choice of other regions.
In general most of the time when I’ve heard people say “us-east-1 is unreliable” it’s ended up that they’re really telling you that they were in just one AZ, thought the RDS multiple AZ mode was too expensive, etc. and standard architectural guidance would have taken care of it.