When a build process is slow, if we are unable to make it fundamentally faster we start to do loads of crazy workarounds that keep growing tentacles with increasing complexity and optimisation challenges: Incremental builds, caching, different pipelines for development vs production. We've been living with this stuff for so long it's easy to forget that when a full build is humanly instantaneous you can just throw all of this complexity away, you don't need it... that's when I realized I could use esbuild, I don't need those "features".
In other words: apples and oranges. :)
But not being able to transpile to ES5 makes it a hard choice to use in client-facing projects, where IE11 is not totally dead (yet).
Its doable to integrate with swc (another great tool on the list), but now the build chain is longer, and more things to take care (such as sourcemaps).