There's an annoying manifestation of this where some games only partially allow remapping controls. For example, when Cyberpunk 2077 was released, it was not possible to rebind to some keys or rebind some actions.

Another pattern I've noticed is some games do not respect Windows' mouse button settings. If other left handed mousers are like me and swap the primary and secondary mouse buttons, they'll probably have noticed that some games ignore this setting and seemingly hard code primary and secondary mouse buttons to be left and right click respectively. The key bindings are understandable to me because nowhere in Windows does it let me set IJKL as my WASD. But I know it's possible to get the primary and secondary mouse button config from the OS but some games ignore or are ignorant of this fact.

Wherever I rebind my keys, I usually start with movement from WASD to IJKL. For everything else, I basically mirror what the default setting is to the right side of the keyboard.

F > H E > U R > Y Q > O C > N L Tab > any of P, Colon, Apostrophe, L square bracket L Shift> any of whatever I didn't use for L Tab X > Comma or M (though comma makes more sense because my right middle finger would type that so it matches developer intention for default setting)

There's actually more keys to choose from on the right side of the keyboard that you can reach with your pinky. This is significant because in some games being able to press buttons while maintaining movement can be advantageous.