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Yes. The days of running a legitimate MTA at home are unfortunately over. Many US-based consumer ISPs block port 25 entirely except for connections to their own MTAs, but for the ones who don't, very very many of those IP addresses wind up on policy-based blacklists -- eg "this network is a bunch of consumer addresses and should never be connecting directly to an MTA"

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Running from home IP sucks for other reasons too, like non-static IP addresses, or lack of public IPv4/use of CGNAT.

I certainly would not risk my emails being delivered to someone else's computer just because IP address changed, and DNS still points to the previous one.

But having the server and data at home is still possible via VPN.

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