The 37signals folks are interesting: as product designers and product managers, I have the utmost respect for them. As observers of the VC scene, their opinions and observations are often useless. That said, if you don't want to go the VC route and instead want to have a go at building a successful business without outside financing, I think Getting Real and Rework are must-reads.

Genius is rarely universal. William Shockley invented the transistor — yes, a gross oversimplification — but was an advocate of eugenics. Henry Ford and Charles Lindbergh? Nazi sympathizers. No, I don't think Jason Fried, DHH, and co. are monsters, but these high-profile examples show that skill, talent, or insight in one area do not necessarily transfer to others. Not everyone is a Leonardo da Vinci.