I have yet to successfully build a project with the strict mypy settings, without resorting to either turning some off or having to use an explicit Any. And a lot of the non-default settings are absolutely critical if you care about correctness.
Lack of recursive types has been a major deal breaker for me. If you have a class Foo that can construct a class Bar, and a class Bar that can construct a class Foo, you can't express that in mypy without Any-Generics.
To me, at this point, mypy is barely a linter, it's more of a "this helps my IDE autocomplete faster", and definitely not a type system.