This could be a game-changer for the infosec community in particular - now, if you want to get into internals, such as tracing file system and registry calls, you've got to write drivers. And drivers are very tricky to write, and it's very easy to miss corner cases - which can result in the dreaded BSOD. Plus, drivers need to go through a verification and signing process by Microsoft.
Having access to that capability from user-mode, without having to write drivers... that would be amazing.