Falcon 9 has lost 2 payloads over ~120 flights. One was lost on the pad prior to dress rehearsal, so doesn't really count.

There were 135 shuttle flights, with 2 crews lost (1 on the way up).

I would much prefer the odds of flying on Falcon 9, especially since it actually has a viable launch escape system.

Both Falcon9 first stage and the Dragon capsule are rated for multiple flights with humans on-board.

They're already launching humans on reused rockets, as of the Crew-2 Mission that launched a couple of weeks ago.

They have re-flown the booster and Dragon2 capsule for the ISS Crew-2 mission.