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I think something along these lines might be possible in the far future.

Imagine using a battery and a small wire to directly enable respiration at the cellular level rather than using oxygen at all.

I can see this greatly facilitating a host of activities on other planets or in space.

That already exists. Surgeons have been using cardiopulmonary bypass machines for years.

What would you replace the lungs with? The space could probably fit a battery and M1 Mac.

arc reactor

You would need to replace them with something that could effectively replace the rectum.