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Seconded. We used the flask-appengine-template (https://github.com/kamalgill/flask-appengine-template) and it's been great so far.

Flask and Jinja2 make views and templates really easy, and the AppEngine data store fits well for the models.

I will third and fourth Flask for App Engine. For me, it strikes exactly the right balance between light-weight, flexible, and powerful.

+1 for Flask here. The documentation especially is on another level. A lot of commitment here with an active developer community.

Agreed. I'm more of a Rails/Sinatra guy but if I had to write something for app engine I'd definitely start with Flask.