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Everyone should read Frank Herbert’s White Plague.

The transmission vector can be anything.

What does a sci-fi author or book have to do anthing with actual investigation of a real-life pandemic?

No answer will be given, of course, but perhaps it can open one's mind to new avenues of thought that may help lead to an/the answer.

In short, enlarging the hypothesis space.

The vulnerable can also be anyone or a subset. I suspect it's inevitable for someone to design a custom virus.