Yes. The [Ctrl|alt]+Shift actually feels more comfortable than a regular keyboard, since it's very easy to stretch the pinky and the thumb, and still have 3 fingers available (you can reach any other key). The same is true in both sections of the keyboard. Learning to use both shift and ctrl keys (depending on which key comes next) is something that takes some getting used to, but feels very natural.

The problem I have with INS is due to it's position, requiring generally the ring finger to overflex to reach it, making it unbalanced to use compared to other keys.