Scrolling vertically is orthogonal to the reading direction. This makes us lose track of scanning head (leading word/sentence) on the content easily. Goes against the grain of our saccadic perception kinda of.
A horizontal flipping transition however, with line-tracking over the text (orphan/widow handling) is the most comfortable book reading experience since it is only intermittently animating—when moving forward to the next page, and connects with the forward flow of storytelling along a groove that our eyes can keep track of.
IMO, page flipping is THE native control of a book and it cannot be dropped off the standards just like that!
I recently read a paper on why an iridescent screen of an iPad or a smartphone is better for the human eyes than a reflective surface of electronic paper like E-ink.
Flux of light.
Intensity or flux is the only parameter that matters to the health of our eyes, and that’s something one could control only with an IPS panel type of screen. Since an e-ink relies on ambient lighting fwiw, low illumination can easily strain the reader’s pupillary muscles and degrade sight sooner.