My dad spent a few years thinking through details about the house before building. Passive radon mitigation was built in (active added later), air exchanger would bring in new air without losing all the heat/cold of the conditioned air, radiant floor heating in the basement, ~24" of blown in insulation in the attic, 6" walls for additional insulation, 24" eves give a bit more shade around the house.
When we installed the fan, the documentation mentioned failure to open 9 square feet or more of outside doors/windows could result in a window breaking from the negative pressure.
A negative pressure house is bad for more than just radon. It can cause certain appliances to vent bad stuff into the house too.
Separately, offgassing is an issue for sofas and mattresses, anything made of particle board as well, but if you put them in a low pressure environment, it doesn't drastically accelerate offgassing. If they offgas formaldehyde, they're going to keep doing it after the low pressure period has ended, so better to avoid those materials altogether.
After mapping out my house we saw numbers as high as 15, 4.0 is the recommended mitigation threshold in the USA, 2.6 for the EU.
After talking to a company they recommended sealing our sump pump area, and then installing a fan that sucked air from under our foundation. Our readings dropped from 15 to 0.5, and stayed there. I do wonder how long the sump pump sealant will last, but I have the airthings to watch.
So sure, open up the windows when you can, but I'm glad I can close the windows when it's smokey or cold and still have low radon levels.