I wrote about this over a year ago over here https://ao.ms/how-to-package-a-python-app-using-nuitka/

I've also used it in a production estate, and it works wonderfully well.

Would recommend!

I've used it for some simple, personal usage CLI tools and simple REST services. Works out-of-the-box and really well.

From my experience some libraries are hard to compile (e.g. BeautifulSoup) but not impossible they need some tweaking.

Sometimes I struggle with embedding data for some reason (especially since I'm spoiled with Go 1.16 `// embed`).