Define "significant".
People who don't graduate high school do much worse than people who graduate from college on average.
Even if you only graduate high school, you'll (on average) make half as much over your lifetime as someone who graduated with a Master's Degree [1].
Right now (on average) - people who dropped out of college make nearly 1/3rd as much as people who graduated with a Master's Degree [2].
You're also 36x more likely to be in prison [3]. Only ~10% of the >25 population has not graduated high school. Despite that, 80% of prisoners have not graduated from high school. ~18% of high school drop outs are in prison. Less than 0.5% of the rest of the population is in prison.
You're also almost 50% more likely to be obese (mostly because you're more likely to be poor and live somewhere un-walkable) [4].
You also have a ~13% shorter lifespan (9 less years) [5].
Sure - an education isn't a license to be in the top 1% or have a perfect life - but it certainly helps...
[1] https://www.aplu.org/projects-and-initiatives/college-costs-...
[2] https://study.com/articles/How_Much_More_Do_College_Graduate...
[3] https://slspotlight.com/opinion/2018/03/19/high-school-dropo...
[4] http://educationbythenumbers.org/content/education-might-be-...
[5] https://www.tc.columbia.edu/articles/2005/october/high-schoo...