Yup. Let’s say the test shows “very likely” for pancreatic cancer.
Now you do imaging. Ok, nothing there? Now what? Biopsy? That’s general anesthesia now and costly (for the patient or govt). Biopsy is negative. Now what? Start chemo? Watch and wait? For how long? Do a biopsy every 6 months?
None of these tests are 100% accurate. If broadly used, a false positive of 0.1% will result in tens of thousands getting unnecessary testing.