I wrote a react application and VDOM overhead was so high that I had to cut down what parts of the UI were rendered to just what was on-screen at any given time. Performance was just barely okay on a desktop and completely unusable on an Android phone.

Not using react made everything work amazingly fine. Granted this was an application with fairly low amounts of DOM manipulation (popup things when the user clicks on stuff, some lists that elements can be added/removed to/from), but those sorts of things seem fairly typical.

I wanted to use React because the code was so much cleaner and concise, but it was just way too slow.