I don't like it too much. It's still based on designing for desktop first.
I prefer the ones that use a mobile first approach, which is more future-proof and is supported on more devices.
Also, another thing to consider is fluid-width vs fixed-width. Fluid width layouts are harder, but much more future proof. The mobile device landscape changes fast, and there are lots of sizes to design for. A fluid-width website would be much better in this case.
Some of these are Gridless[1], HTML5 Boilerplate[2] and 320 and Up[3].
[1]: http://thatcoolguy.github.com/gridless-boilerplate/