Would love to know the dosages they are using in the trials. Obviously, we're not talking McKenna level doses, but are we in milligrams or even as little as micrograms?
https://www.biorxiv.org/content/10.1101/2021.02.17.431629v1....
"Eighty participants, ages 21 to 65, who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for major depressive disorder (MDD) will be stratified by study site and randomized with a 1-to-1 allocation under double-blind conditions to receive a single 25 mg oral dose of psilocybin or a single 100 mg oral dose of niacin. Niacin will serve as an active placebo."
> Eighty participants, ages 21 to 65, who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for major depressive disorder (MDD) will be stratified by study site and randomized with a 1-to-1 allocation under double-blind conditions to receive a single 25 mg oral dose of psilocybin or a single 100 mg oral dose of niacin. Niacin will serve as an active placebo.
I'm not convinced these participants are mice.
(As an aside, I love the way they talk about double blind conditions as if you're not going to be able to tell whether that pill was 25mg of psilocybin.).