+1 for shucking the drive. I got a few WD externals (14 TB). They exhibited the exact behaviour described by OP. Essentially the drive slept every 15 minutes or so.
Smartctl on a timer didn’t work. Touch on a timer didn’t work. I can’t recall if hdparm or some other tuning of sleep and head parking settings worked.
Taking the drive out of the enclosure worked. It got so much quieter too.