I vaguely recall seeing a Mozilla presentation while back saying that they had gone to using 64 bits to store JS variables even on 32-bit machines - this was faster since doubles then fit directly, but presumably on a 64-bit machine it would get faster again.
Edit: http://hacks.mozilla.org/2011/03/firefox4-performance/ refers to 64-bit NaN boxing and links to the article I was thinking of, but unfortunately that seems to be broken.