If it would be possible to install current, plain Linux on a device which can make use of a USB-Hub, in order to add a sound card, video camera, USB-to-serial or whatever it is, then these devices would get a second life.
Imagine a smartphone with a plain Linux on it and an extrenal USB-HDD and USB-to-Ethernet-Adapter attached to it to now serve as a DLNA server, or a simple NAS for a backup of the family's photo collections.
It's theoretically possible, but for some reason removing that Android and fully replacing it with a Linux/GNU system is close to impossible.