Basically they are saying that decades of distributed protein folding was useless and everyone would have had more utility mining cryptocurrency if it existed several years earlier
But at least it inspired someone to make and release this
But at least it inspired someone to make and release this
I think many people believe that given infinite computer time the protein folding simulations would produce the same output as the static prediction (modulo a number of complex details) but use far, far more computer time to get there.
The fundamental observation from the DM AF2 paper that I've been able to glean (which I kind of sort of already believed) is that careful multiple sequence alignments of 30-100 evolutionarily related proteins is enough to produce coarse distance constraints that can be used to guide a structure prediction to a good answer quickly. And that depended on new ML technology that didn't exist before.
> After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold2, at scale to almost the entire human proteome (98.5% of human proteins).
I just don't actually understand the quote from the article if it isn't comparing the same thing
refers to structures determined by means of physical examination, with like crystallography, not to attempts at predictive computational analysis prior to AlphaFold, which were not accurate compared to AlphaFold.